引导RNA(AGCTGGTGAAGAAAGAACCG和CAAGTCAGCTCCAGCTGCCT)被设计用于在Eph受体A1(EREA1)基因的P461位置产生CCG到TTG的错义突变,导致丝氨酸(Pro)变为亮氨酸(Leu),这与人类SNP rs202178565的位置相匹配。人类SNP rs202178565在人EPHA1基因中已被发现,并与散发性阿尔茨海默病(AD)的增加风险相关联。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
核苷酸替换
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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