引导RNA(AGCTGGTGAAGAAAGAACCG和CAAGTCAGCTCCAGCTGCCT)被设计用于在Eph受体A1(EREA1)基因的P461位置产生CCG到TTG的错义突变,导致丝氨酸(Pro)变为亮氨酸(Leu),这与人类SNP rs202178565的位置相匹配。人类SNP rs202178565在人EPHA1基因中已被发现,并与散发性阿尔茨海默病(AD)的增加风险相关联。(来源:J:101977)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count