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中文
V380E (基因座10的GTG替换为GAG)和I391V (exon11的ATT替换为GTG)的基因突变是通过同源重组引入的。在表达FLP重组酶的ES细胞中，位于第9内含子的loxP/FRT引导的诺卡因 cassette被剔除了，留下一对loxP/FRT位点。这些人类化突变使得小鼠对thalidomide类似物敏感。(来源：J:326489)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
