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中文
人体中CYP3A酶在小肠的表达会导致该化合物显著的代谢，影响药物吸收。这种敲入模型是通过将人类CYP3A4的cDNA，由Villin1启动子驱动，并与tdTomato报告基因通过IRESS序列插入，插入到小鼠Rosa26位点产生的。这个模型可以与Cyp3a13基因敲除和其他Cyp3a家族基因敲除的鼠进行杂交，以获得表达人类CYP3A4的小肠特异型基因序列小鼠，以研究小肠代谢对药物吸收和分布的影响。(来源：J:238766)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
