这些小鼠体内携带有loxP位点的STOP cassette,阻止了由CAG启动子驱动的Cas9基因及随后的IRES-Luciferase共表达元件的转录。目标突变通过同源重组插入了Rosa26位点。(来源:J:238766)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
插入
不确定
--
--
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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