Tc(HSA17*P301L)1Mdk

A 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). In this transchromosomal (Tc) strain, the mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT (H1 haplotype) genes. The human MAPT gene was modified to include the P301L (proline to leucine; CCG to CTG) mutation identified in FTDP-17 patients. The loxN-flanked neomycin resistance cassette that was removed by transient cre expression. (J:101977)