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中文
CRISPR/Cas9技术通过sgRNAs(针对TATGTCTCTATGCAGATGCA和ACACTGACAGCCAGCTCTTT)和ssODN模板，成功在exon 5中实现了TACTAC到TTCTTC的变异，导致了酪氨酸( Tyr)变为苯丙氨酸( Phe)的替换，位置是137和138(等位基因p.Y112_Y113delinsFF)。此外，还插入了一个额外的T，形成了一个移码和早停密码子(p.Gly145Leufs*18)。参考文献：J:303558
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
