靶向载体设计用于替换基因的exon 1区域,替换为完整的人类PRL编码序列,后面跟着一个带有floxed Neo cassette的元件。通过Cre介导的重组, Neo cassette被去除了。免疫印迹分析显示这些小鼠不表达内源性泌乳素。(来源:J:324566)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/Sv
Targeted
插入
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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