Stat1^tm1.1Hko

BAC RP23-361H17 was mutagenized to change arginine codon 274 (CGT) in exon 10 to glutamine (CAG) (p.R274Q) and used to replace the endogenous gene via homologous recombination. The loxP site flanked neomycin resistance gene cassette that was inserted into intron 10 was removed through subsequent cre-mediated recombination. The mutation mimics the gain-of-function mutation found in chronic mucocutaneous candidiasis (CMC) patients. (J:324282)