使用sgRNA(靶向AGGCAGCTGATTCTACCAGA)和ssODN模板(AATGGGTGTGTGTTTTTGGGCAAGTATGCTGCATATACAGTTTCAATGGCTTTTCTCAAGGCAGCTGATCCTACGAGTCGGTCTGAAATCTGAAAAATCAAAAGGAGAGTTAACCAGATCACACTTG),通过CRISPR/Cas9技术,GAA编码的谷氨酸(甘氨酸,GAA)被替换为GGA(等位基为GGA,c.803A>G,p.E268G,来源:J:324056)。
Basic Information
FVB/NJ x B6(Cg)-Tyrc-2J/J
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count