使用sgRNA(靶向AGGCAGCTGATTCTACCAGA)和ssODN模板(AATGGGTGTGTGTTTTTGGGCAAGTATGCTGCATATACAGTTTCAATGGCTTTTCTCAAGGCAGCTGATCCTACGAGTCGGTCTGAAATCTGAAAAATCAAAAGGAGAGTTAACCAGATCACACTTG),通过CRISPR/Cas9技术,GAA编码的谷氨酸(甘氨酸,GAA)被替换为GGA(等位基为GGA,c.803A>G,p.E268G,来源:J:324056)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
FVB/NJ x B6(Cg)-Tyrc-2J/J
Endonuclease-mediated
单点
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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