使用单链供体RNA,带有2个GCC突变的CRISPR/cas9导向重组被用来插入W197A变异。第二组目标核苷酸在这个等位基因中没有插入。这个等位基因是在Ifih1tm1Aki纯合小鼠胚胎中创建的,该变异降低了RNA编辑活性。(来源:J:323650)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
核苷酸替换
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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