Mice were generated by inserting a 2A sequence, YFP, 2A sequence, and the N-terminal fragment of improved cre (iCre) recombinase (aa 1-104) fused to the N terminal 102 amino acids of the DnaE split intein sequence from Nostoc punctiforme (Npu), FLAG tag, and Frt-flanked neomycin resistance cassette immediately in front of the stop codon of Sftpc coding sequence by homologous recombination. The Frt-flanked neomycin resistance cassette was removed by crossing with hACTB-Flpe deleter mice. (J:323339)