在exon 1的上游插入了LoxP位点,并将它们插入了内含子1中。后续通过Cre介导的重组删除了exon 1(染色体7:144,581,754-144,584,070,GRCm38.p4)(参考文献J:281456)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count