通过CRISPR/Cas9技术,用sgRNAs(针对TCGAGGATGCCCAGAAGCT和TTCCTAGACTGCAACCGAG)设计,产生了一个142bp的缺失突变位点(ACCATCGAGGATGCCCAGAAGCTATTTC...TGCTGGTCAACTTCCTAGACTGCAACCGAG)。这对应于一个基因敲除等位基因。来源:(J:309361)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count