将靶向构建插入到小鼠基因的起始密码子后第1外显子,该构建包含带有P301L突变和V5标签的人源cDNA isoform 1N4R的floxed转基因。通过Flp介导的重组,去除了转基因5'端的FRT-flanked诺卡因抗性 cassette。(来源:J:321949)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count