CRISPR/cas9通过gRNAs(GGCTCTCCACTTCTAGCTAC和CAACGGATCTTATGAGTTC)引起的一种编辑,产生了一个13,432bp的缺失和一个单个碱基的插入(T),这个区域与人类acheiropodia患者中一个12kb的缺失区域有同源性。(来源:J:306058)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
FVB/NJ
Endonuclease-mediated
插入,基因内删除
--
1
7
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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