Log In|Sign Up
中文
使用含有RMCE准备好的Gt(ROSA)26Sortm1Rkuhn等位基因的ES细胞，原始 cassette被替换为一个载体，包含以下组件：一个attB位点、CAG启动子、一个由loxP序列包裹的 puromycin抗性基因座、一个与人类DROSHA cDNA的E1147K突变及C端FLAG标签的YFP基因，以及第二个attB位点。突变的Drosha仅在cre介导的puro cassette删除后表达。这种突变与Wilms瘤关联，并严重影响到其剪切活性所需的金属结合Drosha。(来源：J:321428)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
