通过CRISPR/Cas9基因编辑技术,Ccl28基因的第2外显子中删除了53bp,导致阅读框移位和早期翻译终止。对来自肺、结肠和唾液腺的CCL28 mRNA进行定量实时PCR(qRT-PCR)分析,结果显示纯合小鼠中没有mRNA存在。(来源:J:321185)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count