在第23外显子的800位和804位(苏氨酸到阿尔法氨基酸的替换,S800A, S804A),以及814位和819位的Thr到Ala替换(Thr814A, Thr819A)被引入,同时在第23外显子下游插入了含loxP标记的PGK-neo。这些改变阻止了这些位置的磷酸化。(来源:J:321600)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
核苷酸替换
--
1
14
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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