Litaf^tm1.1Cwc

Threonine codon 115 (ACC) in exon 3 was changed to asparagine (AAC)(p.T115N) and a loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. The mutation mimics the human mutation associated with CharcotMarieTooth disease type 1C (CMT1C). (J:314784)