为了模拟人类遗传性胰腺炎中与之相关的突变(p.K23R),在第2外显子的第24位,赖氨酸密码子(AAA)被替换为 arginine(AGA),变异为(c.71A>G, p.K24R)。随后,插入了一个由loxP序列引导的诺卡因抗性基因座,并通过Cre介导的重组手段去除。参考文献:(J:320409)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
单点
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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