CRISPR/cas9基因编辑技术用于产生一个390个核苷酸的缺失,导致exon 5的完全丢失。选择的导向RNA针对exon 5上游的[ACTTTCCTATAACCCCAAGT; CTTGGGAGTGACACCTACTT]序列,以及下游的[AAGTAGATTTAGATAAAACT; AGTAGATTTAGATAAAACTT]区域。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
BALB/cByJ
Endonuclease-mediated
基因内删除
--
1
2
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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