这个靶向载体在第一个编码外显子的起始密码子上游插入了loxP位点,并带有3'端的loxP标记的诺卡因抗性基因座(FRT-flanked)。通过Flp酶介导的重组,去除了选择性标记。随后,Cre介导的重组移除了第一个编码序列。(来源:J:318731)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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