CRISPR/cas9基因编辑通过在原设计用于创建条件性敲除突变的外显子4上游(ACTTATACCATCAGTTAGAT; AGCAGGACCAATCTAACTGA)和下游(CTGCTGGCTCATAGTGTGCG; CCCGCACACTATGAGCCAGC)区域使用引导RNA,意外地产生了一个553bp的缺失,包括了整个外显子4(从TCTGCTTAAAGCAGGACCAATCT到/del553/GCGGGGTAGCATTTAAAGGCAGCAC)。(来源:J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count