A gene-targeting vector was generated containing the promoter and exon 1, intron 1, part of exon 2, part of exon 3, intron 3, and exon 4 of the Adm gene upstream of a BamH1 site and a neomycin resistance cassette. The finale allele lacks the coding sequence for the proadrenomedullin N-terminal 20 peptide. (J:286466)