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中文
将缺失胆固醇附着序列且带有p.C25S突变（以阻止肽的棕榈酰化）的鼠 sonic hedgehog 基因cDNA，置于mouse paired related homeobox 1（Prrx1）驱动元件下，使其在胚胎肢体芽发育中表达。NonCholesterol Modified变异是在第3外显子上游的胆固醇结合位点附近插入了loxP序列标记的诺卡因抗性基因座，导致Gly198后出现早停密码子。之后通过Cre介导的重组移除了neo cassette。(来源：J:89228)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
