Tg构建是通过改造小鼠BAC克隆,将核定位信号(Cre-pA) cassette和FRT-Amp-FRT序列插入Prkcd基因的起始翻译位点,生成的。通过细菌中的flp/FRT重组,BAC构建中的Amp序列被去除。在获得的多条品系中,筛选出了一条(P)线,它在背侧丘脑核中具有高特异性的重组选择性。(来源:J:254126)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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