CRISPR/Cas9技术产生了一个180bp的剪切,发生在靠近N端的exon1区域,这对CLIC5的交互是必需的。这导致了第35位氨基酸之后序列的变化,丧失了60个氨基酸,但保持了译码的一致性。(来源:J:314281)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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