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中文
通过在ES细胞中使用同源重组，靶向载体插入了Fndc5基因的exon 2上游的loxP序列，以及FRT介导的Neo选择性元件，随后是exon 2下游的第二个loxP序列。Neo元件通过Flp重组酶被剔除，使得exon 2被loxP座标记。通过Cre介导的exon 2去除，将产生一个75aa（前28aa为irisin的N端序列，后47aa为无义突变的氨基酸）的剪切，产生一个缺失的片段。来源：(J:314278)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
