Syce1^em1Amp

CRISPR/Cas9 technology generated a C to T change at position 613 (c.613C>T) resulting in a glutamine to a premature stop codon at residue 241 (p.Gln241*) which is predicted to generate a truncated product of amino acids 1 to 240. This corresponds to chr7:g.140358157G>A (c.727C>T and p.Q243*) on genome build GRCm39. This is a mutation seen in premature ovarian failure in humans. (J:314193)