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中文
这个转基因包含了以下组件：小鼠Prion蛋白基因的启动子和exon1、 intron1和exon2，一段编码人类Ubqln2 cDNA中proline 506被替换为threonine（p.P506T）的内插FLAG标签的序列，以及Prnp的exon3和下游序列。这种变异与家族性前额叶-颞叶痴呆/肌萎缩侧索硬化症（FTD/ALS）相关。（来源：J:267076）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
