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中文
在exon 2的PPRP密码子91-94位(CCCCCTCGACCG)，目标替换成GGTGTAGCAGCT(等同于p.P91_P94delinsGVAA)，通过设计两份sgRNAs(针对GAGCAACAGGAAGCGGTCGA和TTTGAAGAACCCGGAGCAAC)和一个ssODN模板(GCTACAATGAAACCACTGGGGAGAGGGGAGACTTTCCAGGAACTTACGTTGAATACATTGGAAGGAAAAGAATTTCACCCCCTACTCCCAAGCCTCGGGGTGTAGCAGCTCTTCCTGTTGCTCCGGGTTCTTCAAAAACTGAAGCTGACACGGAGCAGCAAGGTCAGTATGATGAGTGGCTGGTTACTTAATGACCTTTT)，使用CRISPR/Cas9技术进行改造。这种变异使得编码的多肽对炭疽致死毒素的降解有了更强的抵抗性。(来源：J:304170)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
