CRISPR/cas9通过重组产生了C到A的突变,导致DSG域中Alanine被Aspartic acid替换。这个改变预测会干扰该蛋白质的酶活性。(来源:J:311930)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6D2F1
Endonuclease-mediated
核苷酸替换
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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