这个靶向构建替换了编码序列,用了一个含loxP位点、FRT引导的诺卡因抗性元件、人源形式3(E3F)的编码序列(带有信号肽),一个F3标记的 puromycin抗性元件,再加一个loxP位点和人GH的poly(A)序列。通过Flp介导的重组,移除了FRT引导的诺卡因抗性元件。(来源:J:311531)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
7
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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