CRISPR/cas9通过使用双sgRNA(5'-TCGCCTTCAATGCGGATGTCTGG-3'和5'-AGGGTACCGGCGGGTGTTTGAGG-3')引起了exon 2的41bp缺失,导致了frameshift变异。(来源:J:311512)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count