通过CRISPR/Cas9系统,针对小鼠S100a4基因的第二个外显子(exon 2)进行了编辑,目标是产生7个碱基的缺失。这种缺失导致了编码在第二个外显子末尾的氨基酸序列发生框架移位,并在第三个外显子形成一个早闭终止密码子。(来源:J:299945)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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