在该位置插入了451位的 cysteine 被替换为 alanine(C451A)的突变,并插入了由 FRT 立即和 neomycin 选择性座座(selection cassette)环绕的区域。通过 Flp 介导的重组移除了 neomycin 选择性座座。这种突变导致受体的棕榈酰化和膜运输功能丧失。(来源:J:300483)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
核苷酸替换
--
1
4
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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