Signal guide RNAs (GGCTAAGGTTACAAGCCGGG and TAAGAAAGTAAGCAACGAGC) and oligo donor DNAs (CTGAATCCATTTCTGGGAGTGGGATCTTCCACCTTCGTCAGGTGAGGTTTAGGTGAACATCCACCCGTCGACATAACTTCGTATAATGTATGCTATACGAAGTTATGGCTTGT AACCTTAGCCTGCACAACGTCTGCGTAGGCAGCGTGGCCCAGGAGTGGGATGGGCAAGGAG and ATCTAGATGAAGTACCAACTCCAGATTCAAGTGAGAGACCTTCCCCAAATATATAAGAAAGTAAGCAACGTCGACATAACTTCGTATAATGTATGCTATACGAAGTTATAGCCGGGTGTGATGGCGCACACCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGTCTTGTCTACA) are designed to introduce loxP sites and Sal1 restriction sites flanking exons 1-24. (J:323349)