这个转基因构建包含了整个E3A泛素蛋白连接酶(Ube3a)基因;设计时在3-5号外显子周围包含了loxp位点。5号外显子下游仅保留了一个FRT位点(这是由表达FLP的质粒在BAC重组过程中去除的,该位点原本来自FRT引导的zeomycin抗性元件)。(来源:J:244070)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NJ
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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