一种靶向载体,从5'到3'顺序包含猪心肌炎病毒(IRES)启动子、串联二聚体(td)番茄、Thosea asigna病毒的T2A自切割肽、雌激素受体配体结合域的Cre重组酶、牛生长激素poly(A)以及弗里特(Frt)标记的诺卡因抗性基因,被插入到内源性终止密码子下游的第8外显子中。在雄性小鼠中,通过与表达FLP1的雌性杂交,诺卡因选择性基因座被剔除。(来源:J:282429)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
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1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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