在Igf2和H19基因间插入了一个ICR(带有BglII酶切位点,能提供染色质绝缘、启动子沉默和表观遗传印记(不同甲基化)功能的2.4kb片段),这个ICR被一个loxP序列标记的抗氨苄青霉素基因座和含有两拷贝鸡β球蛋白染色质绝缘体(ChbetaGI)2kb序列所替换。随后通过Cre介导的重组,去除了neo cassette。来源:(J:308869)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intergenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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