人类6kb的角蛋白5(KRT5)启动子驱动cre/ERT2 cassette。cre/ERT2由pCI哺乳动物表达载体的内含子和polyadenylation序列环绕。构建物被注入受精卵中,获得了11个杂交瘤系,其中第二线在食管基底细胞中表达,但在气管细胞中不表达。(来源:J:152012)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count