选择的导向RNA(-guide RNAs)为[TGTCTGTGATTTCCTAACGG, TTCACCTAATCACAAGTAAC],它们针对的是编码第3外显子的内含子DNA序列。这种变异是一个2465个碱基的缺失(GTAGTGTCTGTGATT//del 2465//AGGTGAATAAAGATGTCAA),导致基因组中完全丢失了第3外显子(来源:J:101977)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
--
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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