一种融合蛋白,包含内源性核糖体进入点(IRES)、eGFP、Cre和人改造的雌激素受体(ERT2,简称IGCE)的基因,被连接到Frt-flanked Neo编码元件,并插入小鼠Il17a基因的终止密码子下游,通过靶向同源重组在ES细胞中实现。杂交育种后,产生了能传递到后代的转基因小鼠,这些小鼠与表达翻转酶的转基因小鼠交配,以剔除Neo基因。(来源:J:224098)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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