一个81kb的基因组片段,包含了Sprr2a1、Sprr2a2和Sprr2a3,通过CRISPR/Cas9技术被删除了。相关的指导RNA(gRNAs)序列分别是:上游的GTGTAGAAAAAAGGATCGGTGGG,下游的ATTATCAGCGGTGTACTGCCAGG。这个区域位于GRCm38.p6染色体的92,210,732-92,291,813位置。(来源:J:314159)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因间区删除
--
3
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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