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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Del(16Pi4ka-Hira)1Atai
Alias:
Del(3.0Mb)
Del(16Pi4ka-Hira)Atai
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基础信息
表型特征
文献报道
CRISPR/Cas9技术被用来在Pi4ka和Hira之间,包括这两个基因在内,删除了3兆碱基。这个删除区域与22q11.2染色体缺失综合症个体中观察到的3兆碱基缺失相匹配。(来源:J:285407)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
6729278
C57BL/6N
Endonuclease-mediated
Intergenic deletion, Intragenic deletion
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3
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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