在编码第一和第二免疫球蛋白区的外显子前后,分别插入了LoxP位点,这些位点位于BstEII和HpaI酶切位点,距离约500个碱基上游和2100个碱基下游。此外,还插入了一个FRT引导的PGKneo cassette,然后通过与Gt(ROSA)26Sortm1(FLP1)Dym小鼠杂交,通过Cre介导的重组将其去除。这一过程导致了含LoxP序列的片段被剔除。(来源:J:306160)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入,基因内删除
--
1
11
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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