转基因构建包含了小鼠Runx1增强子序列(eR1)和小鼠Hspa1a(热休克蛋白68)底物驱动Cre/ERT2表达的基序。产生了超过10条奠基品系。高拷贝数的TG(5-2)品系和低拷贝数的TG(3-7)品系用于研究。尽管前者Cre重组酶活性较高,但使用这些品系得到的结果在定性上没有差异。(来源:J:299420)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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