通过小鼠胚胎干细胞中同源重组,将cre-SV40表达座、PGK启动子(PGK)后跟着抗氨苄青霉素的耐药基因(Neo),由FRT序列 flank的,插入到了17号染色体Nox3基因的第1外显子的ATG位点。这些奠基小鼠与CAG-FLP小鼠杂交,以剔除Neo基因座,这产生了一个无功能的等位基因。(来源:J:306032)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Targeted
插入
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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