设计了一个靶向载体,用于替换Qrfp基因(Qrfp)在第二外显子的前导序列(prepro-Qrfp序列)中的全部编码区域,用iCre和pgk-Neo座标替换,由内源性Qrfp启动子驱动iCre的表达。通过与FLP66小鼠杂交,去除了pgk-Neo座标。这是一种敲入/敲除突变基因(J:294111)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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