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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Col1a2
em1(cre/ERT2)Bzsh
Alias:
Col1a2-2A-CreER
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基础信息
表型特征
文献报道
通过CRISPR/Cas9技术,这条线通过在Col1a2基因的翻译终止密码子后插入编码cre/ERT2重组酶的cDNA,然后通过自切割肽2A序列以同源方式插入内源性Col1a2。(来源:J:248362)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
6721050
Not Specified
Endonuclease-mediated
插入
--
1
18
3
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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